Method of dissolution of hydroxypropyl methyl cellulose

Hydroxypropyl methyl cellulose, is a nonionic cellulose mixed ether. It is a semi-synthetic, inactive, viscoelastic polymer commonly used as a lubricant in ophthalmology, or as an excipient or excipient in oral medicine.

The following is the solution of hydroxypropyl methyl cellulose:

1, all models can be added to the material by dry mixing method.

2, need to be directly added to the normal temperature water solution, the use of cold water dispersion, after the addition of the general in 10-90 minutes to thicken.

3, Ordinary models are mixed with hot water first and dispersed, and then mixed with cold water to cool and dissolve.

4, When dissolving, if caking occurs, it is because of insufficient stirring or ordinary models directly added to cold water. At this time, it should be stirred quickly.

5,  If bubbles are produced during dissolution, they can be left to stand for 2-12 hours (the specific time is determined by the consistency of the solution) or removed by vacuuming, pressurizing and other methods. Appropriate amount of antifoaming agent can also be added.