Solubility of Hydroxypropyl Methylcellulose (HPMC)

Soluble solvents:

Water: Hydroxypropyl methylcellulose is soluble in water, and the aqueous solution is surface active, highly transparent and stable.

Ethanol/water mixed solution: Hydroxypropyl methyl cellulose (HPMC) can be dissolved in an appropriate ratio of ethanol/water.

Propanol/water mixed solution: Hydroxypropyl methylcellulose can also be dissolved in an appropriate ratio of propanol/water.

Other polar solvents: Hydroxypropyl methylcellulose is also soluble in most polar solvents, such as ethylene dichloride.

Insoluble solvents:

Anhydrous ethanol: Hydroxypropyl methylcellulose is insoluble in anhydrous ethanol.

Ether: Hydroxypropyl methylcellulose is insoluble in ether.

Acetone: Hydroxypropyl methylcellulose is also insoluble in acetone.

HPMC is insoluble in aliphatic hydrocarbons such as vegetable oils, animal oils and mineral oils. These oils are generally considered to be poor solvents for most polymers.

Brief explanation:

Hydroxypropyl methylcellulose is a semi-synthetic, inactive, viscoelastic polymer. Due to its unique chemical structure, it can dissolve in water and various polar solvents to form a solution with high transparency and stable performance. However, due to the chemical properties of some solvents such as anhydrous ethanol, ether and acetone being incompatible with the structure of hydroxypropyl methylcellulose, hydroxypropyl methylcellulose cannot be dissolved in these solvents.

These solubility properties make hydroxypropyl methylcellulose widely used in various application fields, such as ophthalmic lubricants, oral pharmaceutical excipients or excipients, etc.

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